The Bee Bread as Super Food: An up-to-date Review in terms of Chronic Diseases




bee bread, chronic diseases, bee, fermented food, health


The Bee bread, a compound of pollen, honey, and bee salivary secretions, has garnered interest for its potential health advantages. This review synthesizes current scientific knowledge regarding bee bread's status as a superfood, particularly in the context of chronic diseases. It scrutinizes the nutritional profile of bee bread, emphasizing its abundance in vitamins, minerals, proteins, and bioactive compounds. Furthermore, it explores the antioxidant and anti-inflammatory properties associated with bee bread and investigates their potential roles in the prevention and management of chronic diseases. Recent research findings concerning the influence of bee bread on specific chronic conditions, such as cardiovascular diseases, diabetes, and neurodegenerative disorders, are deliberated. Additionally, the review probes potential mechanisms underlying the observed health effects, including the modulation of oxidative stress, inflammation, and cellular signaling pathways. Considering the safety and potential side effects of bee bread consumption, a thorough evaluation of its suitability as a dietary supplement is conducted. Existing gaps in the literature and avenues for future research are identified to inform further exploration into the therapeutic potential of bee bread in the context of chronic diseases. In conclusion, this review amalgamates existing evidence to furnish a comprehensive perspective on bee bread as a superfood, accentuating its conceivable role in fostering health and mitigating chronic diseases. The findings underscore the imperative for sustained research to elucidate the mechanisms of action and to establish evidence-based recommendations for its integration into dietary strategies aimed at enhancing public health.


Baky MH, Abouelela MB, Wang K, Farag MA. Bee Pollen and Bread as a Super-Food: A Comparative Review of Their Metabolome Composition and Quality Assessment in the Context of Best Recovery Conditions. Molecules. 2023;28(2):715.

Kolayli S, Keskin M. Natural Bee Products and Their Apitherapeutic Applications. Vol 66. 1st ed. Elsevier Inc.; 2020.

Yucel B, Topal E, Kosoglu M. Bee Products as Functional Food. Superfood and Functional Food - An Overview of Their Processing and Utilization. 2017;(April).

Kieliszek M, Piwowarek K, Kot AM, Błażejak S, Chlebowska-Śmigiel A, Wolska I. Pollen and bee bread as new health-oriented products: A review. Trends Food Sci Technol. 2018;71:170-180.

Mohammad SM, Mahmud-Ab-Rashid NK, Zawawi N. Stingless Bee-Collected Pollen (Bee Bread): Chemical and Microbiology Properties and Health Benefits. Molecules. 2021;26(4).

Svyatnenko RS, Marynin AI, Litvynchuk SI, Poznyak OM. Comparative analysis of physicochemical parameters of buckwheat perga of honey of different regional origins. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. 2023;25(100):9-13.

Tomás A, Falcão SI, Russo-Almeida P, Vilas-Boas M. Potentialities of beebread as a food supplement and source of nutraceuticals: Botanical origin, nutritional composition and antioxidant activity. J Apic Res. 2017;56(3):219-230.

Bakour M, Laaroussi H, Ousaaid D, et al. Bee Bread as a Promising Source of Bioactive Molecules and Functional Properties: An Up-To-Date Review. Antibiotics. 2022;11(2).

Ćirić J, Haneklaus N, Rajić S, Baltić T, Lazić IB, Đorđević V. Chemical composition of bee bread (perga), a functional food: A review. Journal of Trace Elements and Minerals. 2022;2:100038.

Poyraz F, Yalmanci D, İspirli H, Dertli E. Characterization of Bee Bread Produced with Defined Starter Cultures Mimicking the Natural Fermentation Process. Fermentation. 2023;9(2).

Marcello CA. The Science of Bee Bread Probiotics and Their Impact on Well-Being. Journal of Apitherapy. 2023;10(8):7.

Degrandi-Hoffman G, Corby-Harris V, Carroll M, et al. The importance of time and place: nutrient composition and utilization of seasonal pollens by european honey bees (Apis mellifera l.). Insects. 2021;12(3).

Khalifa SAM, Elashal M, Kieliszek M, et al. Recent insights into chemical and pharmacological studies of bee bread. Trends Food Sci Technol. 2020;97:300-316.

Bleha R, Shevtsova T, Kružik V, et al. Bee breads from eastern ukraine: Composition, physical properties and biological activities. Czech Journal of Food Sciences. 2019;37(1):9-20. doi:10.17221/201/2018-CJFS

Zuluaga CM, Serrato JC, Quicazan MC. Chemical, nutritional and bioactive characterization of Colombian bee-bread. Chem Eng Trans. 2015;43:175-180.

Beykaya M, Tanuǧur Samancl AE, Samancl T, Önder EY, Uzun EM, Tosun F. Investigation of Nutritional and Antioxidant Properties of Anatolian Bee Bread. J Apic Sci. 2021;65(2):255-263.

Ahmad S, Campos MG, Fratini F, Altaye SZ, Li J. New Insights into the Biological and Pharmaceutical Properties of Royal Jelly. International Journal of Molecular Sciences 2020, Vol 21, Page 382. 2020;21(2):382.

Keskin M, Özkök A. α-Amylase Inhibition Properties of Bee Pollen and Bee Bread (Perga). Hacettepe Journal of Biology and Chemistry. 2020;48(4):389-393.

Aylanc V, Falcão SI, Vilas-Boas M. Bee pollen and bee bread nutritional potential: Chemical composition and macronutrient digestibility under in vitro gastrointestinal system. Food Chem. 2023;413:135597.

Marco ML, Sanders ME, Gänzle M, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods. Nat Rev Gastroenterol Hepatol. 2021;18(3):196-208.

Toutiaee S, Mojgani N, Harzandi N, Moharrami M, Mokhberosafa L. In vitro probiotic and safety attributes of Bacillus spp. isolated from beebread, honey samples and digestive tract of honeybees Apis mellifera. Lett Appl Microbiol. 2022;74(5):656-665.

Ertosun S, Aylanc V, Falcão SI, Vilas-Boas M. Thermal Stability and Antioxidant Activity of Bioactive Compounds in Bread Enriched with Bee Pollen and Bee Bread. Antioxidants 2023, Vol 12, Page 1691. 2023;12(9):1691.

Habryka C, Socha R, Juszczak L. The Influence of Bee Bread on Antioxidant Properties, Sensory and Quality Characteristics of Multifloral Honey. Applied Sciences 2023, Vol 13, Page 7913. 2023;13(13):7913.

Didaras NA, Karatasou K, Dimitriou TG, Amoutzias GD, Mossialos D. Antimicrobial Activity of Bee-Collected Pollen and Beebread: State of the Art and Future Perspectives. Antibiotics 2020, Vol 9, Page 811. 2020;9(11):811.

Pełka K, Otłowska O, Worobo RW, Szweda P. Bee Bread Exhibits Higher Antimicrobial Potential Compared to Bee Pollen. Antibiotics. 2021;10(2):1-14.

Caner A, Onal MG, Silici S. The effect of bee bread (Perga) with chemotherapy on MDA-MB-231 cells. Mol Biol Rep. 2021;48(3):2299-2306. doi:10.1007/S11033-021-06259-3

Li Z, Huang Q, Liu Y, Peng C, Zeng Z. Natural bee bread positively regulates lipid metabolism in rats. J Agric Sc Food Technol. 2021;7(3):266-271.

Othman ZA, Zakaria Z, Suleiman JB, Che Jalil NA, Wan Ghazali WS, Mohamed M. Bee bread attenuates the progression of atherosclerosis by activating Nrf2/Keap1 and modulating TNF-α/NF-κβ-associated mast cell migration and a mitochondrial-dependent apoptotic pathway in the obese rat model. Food Funct. 2022;13(15):8119-8130.

Kosedag M, Gulaboglu M. Pollen and bee bread expressed highest anti-inflammatory activities among bee products in chronic inflammation: an experimental study with cotton pellet granuloma in rats. Inflammopharmacology. 2023;31:1967-1975.

Capcarova M, Kalafova A, Schwarzova M, et al. Consumption of bee bread influences glycaemia and development of diabetes in obese spontaneous diabetic rats. Biologia (Bratisl). 2020;75(5):705-711.

Sheu MB. The Effect of Beebread on Wound Healing in Malnourished Rabbits. Ph.D. Thesis. Universiti Sains; 2014.

Doğanyiğit Z, Yakan B, Soylu M, Kaymak E, Silici S. The effects of feeding obese rats with bee bread on leptin and ghrelin expres. Turkish Journal of Zoology. 2020;44(2):114-125.

Suleiman JB, Mohamed M, Bakar ABA, Zakaria Z, Othman ZA, Nna VU. Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model. Antioxidants. 2022;11(2).

Eleazu C, Suleiman JB, A. Othman Z, Zakaria Z, Nna VU, Mohamed M. Effect of bee bread on some biochemical parameters and skeletal muscle histology of high-fat diet-induced obese Sprague-Dawley rats. J Food Biochem. 2021;45(2):1-12.

Martiniakova M, Blahova J, Kovacova V, et al. Bee bread can alleviate lipid abnormalities and impaired bone morphology in obese zucker diabetic rats. Molecules. 2021;26(9):1-14.

Bello M, Umar ZU, Mainasara AS, et al. Effects of Bee Bread on Serum Lipid Profile in Alloxan Induced Diabetic Female Rats. J Adv Med Pharm Sci. 2023;25(10):41-46.

Dervisoglu G, Cobanoglu DN, Yelkovan S, Karahan D, Cakir Y, Kocyigit S. Comprehensive Study on BeeBread: Palynological Analysis, Chemical Composition, Antioxidant and Cytotoxic Activities. International Journal of Secondary Metabolite. 2022;2022(2):166-177.

Zakaria Z, Othman ZA, Suleiman JB, et al. Hepatoprotective Effect of Bee Bread in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Rats: Impact on Oxidative Stress and Inflammation. Antioxidants 2021, Vol 10, Page 2031. 2021;10(12):2031.

Chen CK, Ping FWC, Ooi FK, Mohamed M. Effects of bee bread supplementation during recovery on time trial performance and selected physiological parameters. Int J Pharma Bio Sci. 2018;9(2).

Fadzel WCP, Chen CK, Ooi FK, Mohamed M. Effects of bee bread supplementation on endurance running performance and total antioxidant status in recreational athletes. International Journal of Applied Research in Natural Products. 2018;11(1):17-23.

Bobis O, Marghitas L, Dezmirean D, Morar O, Bonta V, Chirila F. Quality parameters and nutritional value of different commercial bee products. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj–Napoca Animal Science and Biotechnologies. 2010;67(1-2):91-96.



How to Cite

NAHYA, N. (2024). The Bee Bread as Super Food: An up-to-date Review in terms of Chronic Diseases. Advances in Chronic Diseases, 1(1), 37–43.