Current Treatment Approaches for The Management of Guillain Barre Syndrome: A Narrative Review of Physiotherapy Approaches

Current Treatment Approaches for The Management of Guillain Barre Syndrome

Authors

DOI:

https://doi.org/10.5281/zenodo.10893145

Keywords:

Guillain-Barre Syndrome, Physiotherapy, Multidisciplinary Rehabilitation

Abstract

In this review we explore the current physiotherapy treatment approaches for Guillain-Barre Syndrome (GBS), an immune-mediated peripheral nervous system disorder. Examining GBS epidemiology reveals its rarity, diverse clinical variants, and increased incidence with age. The pathogenesis involves subtypes like acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and axonal variants, with infections, particularly C. jejuni, playing a role. The diagnostic methods include nerve conduction velocity tests and cerebrospinal fluid examination. GBS is characterized by progressive complications, ranging from muscular weakness to cardiovascular issues. The crucial role of physiotherapy in GBS assessment and treatment is emphasized, covering various evaluations and rehabilitation strategies. Multidisciplinary rehabilitation, exercise training, pulmonary rehabilitation, electrical stimulation, robotic rehabilitation, virtual reality, and alternative therapies are discussed.  This article stresses the need for high-quality trials, especially in the context of the observed connection between COVID-19 and GBS. It underscores the importance of physiotherapy in GBS treatment, prompting further research and consideration of alternative methods like telerehabilitation.

References

- Khan, F. (2004). Rehabilitation in Guillain Barre syndrome. Aust Fam Physician, 33(12):101

- Leonhard, S., Mandarakas, M., Gondim, FdA., Bateman, K., Ferreira M, Cornblath D, et al. (2019). Diagnosis and management of Guillain–Barré syndrome in ten steps. Nature Reviews Neurology, 15, 1-13.

- Sejvar, J. J., Baughman, A. L., Wise, M. & Morgan, O. W. (2011).Population incidence of Guillain- Barré syndrome: a systematic review and meta- analysis Neuroepidemiology, 36, 123–133.

- Aragonès, J. M., Altimiras, J., Alonso, F., Celedón, G., Alfonso, S., Roura, P., & Moreira, A. (2021). Incidence and clinical characteristics of Guillain-Barré syndrome in Osona (Barcelona, Spain), 2003-2016. Neurología (English Edition), 36(7), 525-530.

- Khan, F., Ng, L., Amatya, B., Brand, C., Turner-Stokes, L. (2010). Multidisciplinary care for Guillain-Barré syndrome. Cochrane Database Syst Rev.,10.

- Hughes, RAC., Wijdicks, EFM., Benson, E., Cornblath, DR., Hahn, AF., Meythaler, JM., et al. (2005). Supportive care for patients with Guillain-Barré syndrome. Arch Neurol., 62(8), 1194–8.

- Abu-Rumeileh, S., Abdelhak, A., Foschi, M., Tumani, H., Otto, M. (2021). Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases. J Neurol., 268(4):1133-1170. doi:10.1007/s00415-020-10124-x

- Tutar, NK., Eyigürbüz, T., Yildirim, Z., Kale, N. (2021). A variant of Guillain-Barre syndrome after SARS-CoV-2 vaccination: AMSAN. Guillain–Barré-szindróma SARS-CoV-2-vakcinációt követően. Ideggyogy Sz. 74(7-08):286-288. doi:10.18071/isz.74.0286

- Burns, TM. (2008). Guillain-Barré syndrome. Semin Neurol., 28(2), 152–67.

- Hughes, RAC., Wijdicks, EFM., Benson, E., Cornblath, DR., Hahn, AF., Meythaler, JM., et al.(2005). Supportive care for patients with Guillain-Barré syndrome. Arch Neurol., 62(8):1194–8.

- Van den Berg, B., Walgaard, C., Drenthen, J., Fokke, C., Jacobs, BC., van Doorn, PA.( 2014). Guillain-Barré syndrome: pathogenesis, diagnosis, treatment, and prognosis. Nat Rev Neurol.,10(8), 469–82.

- van Doorn, PA., Ruts, L., Jacobs, BC. (2008). Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol., 7(10), 939–50.

- Willison, HJ. (2006). Ganglioside complexes as targets for antibodies in Miller Fisher syndrome. J Neurol Neurosurg Psychiatry, 77, 1002-3.

- Sheik, KA., Nachamkin, I., Ho, TW., Willison, HJ., Veitch, J., Ung, H., et al. (1998). Campylobacter jejuni lipopolysaccharides in Guillain–Barré syndrome: Molecular mimicry and host susceptibility. Neurology, 51, 371-8.

- Vriesendorp, FJ., Mishu, B., Blaser, MJ., Koski, CL. (1993). Serum antibodies to GM1, GD1b, peripheral nerve myelin, and Campylobacter jejuni in patients with Guillain–Barré syndrome and controls: Correlation and prognosis. Ann Neurol, 34, 130-5.

- Meena, A. K., Khadilkar1, S.V., Murthy, J.M.K. (2011). Treatment guidelines for Guillain–Barré Syndrome. Annals of Indian Academy of Neurology, 14, 73-81.

- Khan, F., Ng, L., Amatya, B., Brand, C., Turner-Stokes, L. ( 2011). Multidisciplinary care for Guillain-Barré syndrome. Eur J Phys Rehabil Med., 47(4), 607–12.

- Meythaler, JM., DeVivo, MJ., Braswell, WC.(1997). Rehabilitation outcomes of patients who have developed Guillain-Barré syndrome. Am J Phys Med Rehabil Assoc Acad Physiatr., 76(5), 411–9.

- Mukerji, S., Aloka, F., Farooq, MU., et al.(2009). Cardivascular complications of the Guillain Barré syndrome. Am J Cardiol, 104, 1452-5.

- Asbury, AK., Cornblath, DR. (1990). Assessment of current diagnostic criteria for Guillain-Barré syndrome. Ann Neurol, 27, 21–24.

- Van den Berg, B., Walgaard, C., Drenthen, J., et al. (2014). Guillain-Barré syndrome: pathogenesis, diagnosis, treatment, and prognosis. Nat Rev Neurol, 10, 469-82.

- Ropper, AH., Shahani, BT. (1984). Pain in Guillain-Barre syndrome. Arch Neurol, 41, 511-514.

- Mishra, A., Dave, N., Mehta, M. (2014). Fulminant guillain-barré syndrome with myocarditis. J Family Med Prim Care, 3, 84-5.

- Merkies, ISJ., Schmitz, PIM., Samijn, JPA., van der Meché, van Doorn, PA. (1999). Fatigue in immune mediated polyneuropathies. Neurology, 53, 1648–1654.

- Wang, Y., Zhang, H. L., Wu, X., & Zhu, J. (2016). Complications of Guillain-Barré syndrome. Expert review of clinical immunology, 12(4), 439–448. https://doi.org/10.1586/1744666X.2016.1128829

- Monroy-Gómez, J., Torres-Fernández, O.(2020). Effects of the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) on the nervous system. What can we expect from SARS -CoV-2?. Efectos de los coronavirus del síndrome respiratorio agudo grave (SARS-CoV) y del síndrome respiratorio del Medio Oriente (MERS-CoV) en el sistema nervioso. ¿Qué esperar del SARS-CoV-2? Biomedica, 40(Supl. 2), 173-179. doi:10.7705/biomedica.5682

- Moreno-Pérez, O., Merino, E., Leon-Ramirez, JM., et al. (2021). Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. J Infect., 82(3), 378-383. doi: 10.1016/j.jinf.2021.01.004

- Sharifian-Dorche, M., Huot, P., Osherov, M., et al. (2020). Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic. J Neurol Sci, 417,117085. doi: 10.1016/j.jns.2020.117085

- Khalifa, M., Zakaria, F., Ragab, Y., et al. ()Guillain-Barré Syndrome Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Detection and Coronavirus Disease 2019 in a Child. J Pediatric Infect Dis Soc. 2020;9(4):510-513. doi:10.1093/jpids/piaa086

- Kakumoto, T., Kobayashi, S., Yuuki, H., et al. (2021). Cranial Nerve Involvement and Dysautonomia in Post-COVID-19 Guillain-Barré Syndrome. Intern Med, 60(21), 3477-3480. doi:10.2169/internalmedicine.7355-21

- Masuccio, F. G., Comi, C., & Solaro, C. (2022). Guillain-Barrè syndrome following COVID-19 vaccine mRNA-1273: a case report. Acta neurologica Belgica, 122(5), 1369–1371. https://doi.org/10.1007/s13760-021-01838-4

- Finsterer, J. (2021). Exacerbating Guillain-Barré Syndrome Eight Days after Vector-Based COVID-19 Vaccination. Case Rep Infect Dis, 3619131. doi:10.1155/2021/3619131

- Garnés-Camarena, O., Díaz-Cano, G., & Stashuk, D. (2021). Motor unit electrophysiological changes in Guillain-Barré syndrome in the context of a COVID-19 infection. Muscle Nerve, 64(5), E23-E25. doi:10.1002/mus.27407

- Hussain, F. S., Eldeeb, M. A., Blackmore, D., & Siddiqi, Z. A. (2020). Guillain Barré syndrome and COVID-19: Possible role of the cytokine storm. Autoimmun Rev, 19(12), 102681. doi:10.1016/j.autrev.2020.102681

- Farias Feitosa, T., Queiroz dos Santos Dantas, M., Brito da Silva, C., & Pereira, Á. (2016). Monofilament for preventing the diabetic foot: an integrative review of the literature. Online Brazilian Journal of Nursing, 15(2), 291-301.

- Hillier, S., Immink, M., & Thewlis, D. (2015). Assessing Proprioception: A Systematic Review of Possibilities. Neurorehabil Neural Repair, 29(10):933-49.

- Mahler, D. A. (2005). Measurement of dyspnea ratings during exercise. Clinical ratings. In: Mahler DA, O’Donnell DE (eds). Dyspnea 2nd Ed. Lung Biology in Health and Disease. Taylor & Francis, Boca Raton, 208, 167-82.

- Asberg, K. H., & Sonn, U. (1989). The cumulative structure of personal and instrumental ADL. A study of elderly people in a health service district. Scand J Rehabil Med, 21, 171-177.

- Mahoney, F. I., & Barthel, D. B. (1965). Functional evaluation: the Barthel Index. Md State Med J, 14, 61-65.

- Wade, D. T., Leigh-Smith, J., & Langton Hewer, R. (1985). Social activities after stroke: measurement and natural history using the Frenchay Activities Index. Int Rehabil Med, 7, 176-181.

- Bergner, M., Bobbitt, R. A., Carter, W. B., & Gilson, B. S. (1981). The Sickness Impact Profile: development and final revision of a health status measure. Med Care, 19, 787-805.

- Güler, T., Yurdakul, F. G., Acar Sivas, F., et al. (2021). Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes. Rheumatol Int, 41, (12), 2167-2175. doi:10.1007/s00296-021-05003-1

- Khan, F., & Amatya, B. (2012). Rehabilitation interventions in patients with acute demyelinating inflammatory polyneuropathy: A systematic review. European Journal of Physical and Rehabilitation Medicine, 48(3), 507–522.

- Khan, F., Pallant, J. F., Amatya, B., Ng, L., Gorelik, A., & Brand, C. (2011). Outcomes of high- and low-intensity rehabilitation programme for persons in chronic phase after Guillain-Barre syndrome: A randomized controlled trial. Journal of Rehabilitation Medicine, 43(7), 638–646.

- Ko, J., Ha, K. C., Kang, G. J., & Jung, S. (2017). Effects of daily living occupational therapy and resistance exercise on the activities of daily living and muscular fitness in Guillain-Barre syndrome: a case study. Journal of Physical Therapy and Science, 29(5), 950–953.

- Arsenault, N. V., Shen, Y., Bastien, R., Sweeney, A., & Zhu, S. (2016). Influence of Exercise on Patients with Guillain-Barre Syndrome: A Systematic Review. PubMed, 68(4), 367-376.

- Vispute, A. R., & Kanase, S. B. (2020). The effect of proximal muscle strengthening on distal muscle facilitation in Guillain Barre Syndrome. J Evolution Med Dent Sci, 9(37), 2741-2745. DOI: 10.14260

- Orsini, M., De Freitas, M. R. G., & Nascimento, O. J. M. (2008). Effectiveness of an individualized program, based on proprioceptive neuromuscular facilitation techniques in a patient with inclusion body myositis with HIV infection: Description and Preliminary Results. Supplement to Neurology I, 70(11), A146.

- Thomas, M. (2005). Peripheral Neuropathy. In: DeLisa JA, editors. Physical Medicine & Rehabilitation: Principles and Practice. 4th ed. Philadelphia: Lippincott Williams & Wilkins; p.895-912.

- Morgan, M., & Singh, S. (1997). Practical Pulmonary Rehabilitation. London: Chapman & Hall; p.1-8.

- Anonyma. (2013). Physiotherapy Exercises to Mobilize the Chest.

- Narasimman, S., & Praveen, J. (2009). Effect of Inspiratory Muscle Training in Early Rehabilitation of Guillain-Barre Syndrome: Case Reports. The Physiotherapy, 01(01), 13-6.

- Rabinstein, A. (2007). GBS. The Open General and Internal Medicine Journal, 1, 13-22.

- Lawn, N. D., Fletcher, D. D., Henderson, R. D., Wolter, T. D., & Wijdicks, E. F. (2001). Anticipating mechanical ventilation in Guillain-Barré syndrome. Archives of neurology, 58(6), 893–898. https://doi.org/10.1001/archneur.58.6.893

- Hughes, R. A., Wijdicks, E. F., Benson, E., Cornblath, D. R., Hahn, A. F., Meythaler, J. M., et al. (2005). Supportive care for patients with Guillain-Barré syndrome: Multidisciplinary Consensus Group. Arch Neurol, 62, 1194–8.

- Fish, M., & Llewelyn, G. (2008). The Guillain Barre Syndrome. Review Article. ACNR, 8(4), 10.

- van den Berg, B., Storm, E. F., Garssen, M. J. P., Blomkwist-Markens, P. H., & Jacobs, B. C. (2018). Clinical outcome of Guillain-Barré syndrome after prolonged mechanical ventilation. Journal of neurology, neurosurgery, and psychiatry, 89(9), 949–954. https://doi.org/10.1136/jnnp-2018-317968

- Soryal, I., Sinclair, E., Hornby, J., & Pentland, B. (1992). Impaired joint mobility in Guillain-Barre syndrome: a primary or a secondary phenomenon? J Neurol Neurosurg Psychiatry, 55, 1014-1017.

- Maddocks, M., Gao, W., Higginson, I. J., & Wilcock, A. (2013). Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease. Cochrane Database Syst Rev, 1 Art. No: CD009419. DOI: 10.1002/14651858.CD009419.pub2.

- Maffiuletti, N. A., Roig, M., Karatzanos, E., & Nanas, S. (2013). Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review. BMC Med, 11, 137.

- Kern, H., & Carraro, U. (2014). Home-Based Functional Electrical Stimulation for Long-Term Denervated Human Muscle: History, Basics, Results and Perspectives of the Vienna Rehabilitation Strategy. Eur J Transl Myol, 24, 3296.

- Harbo, T., Markvardsen, L., Hellfritzsch, M., Severinsen, K., Nielsen, J., & Andersen, H. (2019). Neuromuscular electrical stimulation in early rehabilitation of Guillain-Barré syndrome: A pilot study. Neurorehabilitation and Neural Repair, 33(4), 481-484.

- Mazzoleni, S., Focacci, A., Franceschini, M., et al. (2017). Robot-assisted end-effector based gait training in chronic stroke patients: A multicentric uncontrolled observational retrospective clinical study. NeuroRehabilitation, 40(4), 483–492.

- Billinger, S. A., Arena, R., Bernhardt, J., et al. (2014). Physical activity and exercise recommendations for stroke survivors: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 45(8), 2532–53.

- Yeon Rhee, S., Jeon, H., Kim, S., & Lee, J. (2020). The effect of an end-effector type of robot-assisted gait training on patients with Guillain-Barre syndrome: A cross-sectional study. 9:1465. doi.org/10.12688/f1000research.26246.1

- EL, M., Calmels, P., Camdessanche, JP., Gautheron, V., Feasson L. (2007). Muscle strength recovery in treated Guillain-Barré syndrome: A prospective study for the first 18 months after onset. Neurology, 86(9), 716-724.

- Alboil-Perez, S., Forcano-Garcia, M., Munoz-Tomas, Manzano-Fernandez, Solsona-Hernandez, Mashat Ma, et al. (2015). A Novel Virtual Motor Rehabilitation System For Guillain-Barré Syndrome. Two Single Case Studies. Journal of Neuroengineering and Rehabilitation, 54(2), 127-134.

- Mooventhan, A., & Nivethitha, L. (2017). Evidence-based effects of yoga in neurological disorders. PubMed, 43, 61-67. Available from: PMID: 28599839.

- Sendhilkumar, R., Gupta, A., Nagarathna, R., & Arun B. Taly (2013). Effect of pranayama and meditation as an add-on therapy in rehabilitation of patients with Guillain-Barré syndrome: Randomized control pilot study. Disability and Rehabilitation, 35(1), 57-62.

- Fan, Z., Liu, B., Zhang, Y., Li, M., & Lu, T. (2020). The effectiveness and safety of acupuncture therapy for Guillain-Barré syndrome: A systematic review and meta-analysis protocol. Medicine, 99(2), e18619. https://doi.org/10.1097/MD.0000000000018619

- White, C. M., Hadden, R. D., Robert-Lewis, S. F., McCrone, P. R., & Petty, J. L. (2015). Observer blind randomised controlled trial of a tailored home exercise programme versus usual care in people with stable inflammatory immune mediated neuropathy. BMC neurology, 15, 147. https://doi.org/10.1186/s12883-015-0398-x

Published

2024-03-29

How to Cite

Amer, M., Muriqi, X., Khosravi, M., Şenel, M., & Mustafaoglu, R. (2024). Current Treatment Approaches for The Management of Guillain Barre Syndrome: A Narrative Review of Physiotherapy Approaches: Current Treatment Approaches for The Management of Guillain Barre Syndrome. Advances in Chronic Diseases, 1(1), 14–27. https://doi.org/10.5281/zenodo.10893145

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